Opioids and Opiates: Demystifying a Demonized Substance

Have you ever wondered what the difference between an “opiate” and an “opioid” is? Perhaps you’re curious as to what the practical difference between heroin and fentanyl is. Or, maybe you’re curious as to what a morphine glow feels like. You’ll find all of that (and more!) on this page.

What’s the difference between an Opiate and an Opioid?

Opiates and opioids get a bad wrap thanks to the illicit fentanyl that is responsible for the vast majority of death and overdoses we’re witnessing. While often used interchangeably, these terms refer to two distinct groups within the broader category of pain-relieving substances.

Opiates, strictly speaking, are only the naturally occurring compounds found within the opium poppy plant. Examples of opiates include morphine and codeine, which are extracted from the plant and used in their natural form. These substances have been used for centuries, if not millennia, for their analgesic properties and their ability to produce feelings of euphoria and relaxation.

Opioids, on the other hand, encompass a wider range of substances, including both natural opiates and synthetic or semi-synthetic drugs that are designed to mimic the effects of natural opiates. Semi-synthetic opioids, such as heroin, oxycodone, and hydrocodone, are chemically modified derivatives of natural opiates, enhancing their potency and effectiveness. Synthetic opioids, such as fentanyl, methadone, and tramadol, are entirely man-made in laboratories and crafted to target opioid receptors in the brain with precision. These synthetic variations can be significantly more potent than their natural counterparts. The main difference lies in their origin: opiates are natural, while opioids can be either natural, semi-synthetic, or fully synthetic, broadening the scope of pain management options and recreational experiences. The image gallery below are all opioids, but only some of them are opiates.

All Opiates are Opioids, but not the other way around.

Just like all apples are fruits, but not all fruits are apples. Now, let’s explore some specific opioids, form their creation or discovery, to the way they feel when used. Note: Opium is not included in this list for two reasons: because it’s becoming increasingly rare, and because it’s a combination of two other opioids (morphine and codeine).

There are three categories of Opioids:

• Natural – These can be found in nature. Codeine and Morphine are the main two.
• Semisynthetic – Derived from natural compounds, but not found in the opium poppy. Examples include oxycodone and heroin.
• Synthetic (or fully-synthetic) – Completely lab-created, these opioids are never found in nature. Substances like methadone, fentanyl and carfentanil are included in this category.

Opiates and Opioids: Types, Creation, and Experiences

Known for their powerful effects on the mind and body, these compounds, whether used for medical purposes or recreational enjoyment, offer a range of unique experiences. Regardless of their particular origins, all opioids share some common properties, including: analgesia (pain relief), respiratory depression, and meiosis (pinpoint pupils).

Characteristics of Opioids

1. Morphine: Opiate (Naturally Occuring)

Creation: Extracted directly from the opium poppy.

Characteristics: Morphine is renowned for its powerful pain-relieving properties and ability to induce a state of euphoria and deep relaxation. Users often describe a warm, enveloping sensation that permeates the body, which is sometimes referred to as a “morphine glow.”

2. Codeine: Opiate (Naturally Occuring)

Creation: Also derived from the opium poppy but in smaller quantities than morphine.

Characteristics: Codeine offers milder pain relief and a calming effect. It’s often found in combination with other medications to enhance its analgesic properties.

3. Heroin (Semi-synthetic)

Creation: Synthesized from morphine through a chemical process that enhances its potency and onset of action.

Characteristics: Heroin is celebrated for its rapid onset of intense euphoria and relaxation, known as a “rush.” Users experience a profound sense of well-being and tranquility, making it a popular choice for those seeking a powerful, euphoric high.

4. Oxycodone and Hydrocodone (Semi-synthetic)

Creation: Derived from thebaine, an alkaloid found in the opium poppy, and chemically modified.

Characteristics: Both drugs provide significant pain relief and are known for their euphoric effects. Oxycodone, often found in OxyContin, delivers a strong sense of well-being, while hydrocodone, found in Vicodin, offers a slightly milder euphoria. Both are highly regarded for their ability to induce relaxation and contentment.

5. Fentanyl (Synthetic)

Creation: Fully synthesized in laboratories to be incredibly potent.

Characteristics: Fentanyl is exceptionally powerful, providing rapid and intense pain relief along with a sense of sedation. Its high potency makes it a standout choice for managing severe pain and for those seeking a potent, euphoric experience.

6. Methadone (Synthetic)

Creation: Fully synthesized in labs as a long-acting opioid.

Characteristics: Methadone gets a bad wrap because of the horror stories about its prolonged and painful withdrawal. It offers sustained pain relief with a gentle euphoric effect. It’s particularly valued in addiction treatment programs for its ability to reduce withdrawal symptoms and cravings, providing a stable, prolonged sense of relief and well-being.

7. Tramadol (Synthetic)

Creation: Fully synthesized in laboratories with additional serotonin and norepinephrine reuptake inhibition properties.

Characteristics: Tramadol combines pain relief with little euphoria and mood enhancement. Its unique properties make it a commonly prescribed medication.

Personal Experiences with Opiates and Opioids

Users often report a range of pleasurable sensations when using opiates and opioids, including:

• Euphoria: A heightened state of happiness and well-being.
• Increased Energy: Some users (myself included) report increased energy levels under the effects of natural or semisynthetic opioids (such as morphine, heroin, and oxycodone in particular).
• Relaxation: A sense of calmness and serenity.
• Pain Relief: Effective alleviation of physical discomfort and pain (analgesia).
• Irritability: While not commonly documented, in my experience, heroin, oxycodone, and methadone all gave me a shorter fuse with regard to irritability. It was a contradictory experience. On the one hand, I felt euphoric and fantastic, while at the same time feeling easily irritated by sounds and people.

In Summary….

…opiates and opioids offer a fascinating array of experiences, appealing to both medical patients seeking relief from pain and recreational users seeking euphoric sensations. The differences in their creation and characteristics provide a diverse palette of effects, from the gentle warmth of morphine to the intense rush of heroin or the potent and often deadly effects of fentanyl. Understanding these differences enriches our appreciation for these substances and their profound effects on the human experience. Whether used as prescribed for medical purposes or enjoyed recreationally, opiates and opioids continue to captivate and provide relief to countless individuals worldwide.

If you’re ready to help us effect the change necessary to save lives and increase our liberty, consider:

It’s high time for change.